【Key Points】 - Proven that natural bacteria collected from the guts of amphibians and reptiles can completely eliminate cancer tissue with a single dose. - Achieves both direct cancer cell killing by the bacteria and indirect attack via immune system activation. - Shows therapeutic effects surpassing existing chemotherapy or immunotherapy with no adverse effects on normal tissues. - Expected to be applicable to various solid tumors, paving the way for the development of new cancer treatments.

A research team led by Professor Eijiro Miyako from the Japan Advanced Institute of Science and Technology (JAIST) screened 45 bacterial strains from the guts of Japanese tree frogs, red-bellied newts, and Japanese grass lizards. They discovered that Ewingella americana, isolated from the gut of the Japanese tree frog, has a powerful anticancer effect that completely eliminates tumors in mouse cancer models with a single administration. The results were published in Gut Microbes.

【Research Details】 ・Phenomenal therapeutic effect In a mouse colorectal cancer model, a single intravenous administration of E. americana achieved a 100% complete response (CR) rate.

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Figure 1. Anticancer effect: Comparison between Ewingella americana and existing treatments

・Anticancer effect through dual action 1. Direct killing effect: Selectively accumulates in hypoxic cancer tissues and directly destroys cancer cells. 2. Immune activation effect: Stimulates the immune system to induce apoptosis in cancer cells.

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Figure 2. Antitumor mechanism of Ewingella americana

・Tumor-specific accumulation and excellent safety Confirmed high safety as it does not settle in normal tissues, selectively accumulates only in cancer tissues, and is completely cleared from the blood after 24 hours.

【Future Developments】 and 【Terminology】 ... (including paper info)